A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk

RC Travis; PN Appleby; RM Martin; JMP Holly; D Albanes; A Black; HB Bueno-De-Mesquita; JM Chan; C Chen; MD Chirlaque; MB Cook; M Deschasaux; JL Donovan; L Ferrucci; P Galan; GG Giles; EL Giovannucci; MJ Gunter; LA Habel; FC Hamdy; KJ Helzlsouer; S Hercberg; RN Hoover; JAMJL Janssen; R Kaaks; T Kubo; L Le Marchand; EJ Metter; K Mikami; JK Morris; DE Neal; ML Neuhouser; K Ozasa; D Palli; EA Platz; MN Pollak; AJ Price; MJ Roobol; C Schaefer; JM Schenk; G Severi; MJ Stampfer; P Stattin; A Tamakoshi; CM Tangen; M Touvier; NJ Wald; NS Weiss; RG Ziegler; TJ Key; NE Allen

Journal article

A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk

RC Travis, PN Appleby, RM Martin, JMP Holly, D Albanes, A Black, HB Bueno-De-Mesquita, JM Chan, C Chen, MD Chirlaque, MB Cook, M Deschasaux, JL Donovan, L Ferrucci, P Galan, GG Giles, EL Giovannucci, MJ Gunter, LA Habel, FC Hamdy Show all

Cancer Research | Published : 2016

DOI: 10.1158/0008-5472.CAN-15-1551

Abstract

The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was ..

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